The Midwest Tumor Microenvironment (MWTME) conference returns to Madison! This two-day meeting has been taking place annually since the inaugural event at the University of Wisconsin Madison in 2015. The conference has been hosted by several Midwest universities including: the University of Minnesota (’16), Washington University (’17), the University of Iowa (’18), University of Notre Dame (’19), the University of Kansas online (’21) and in person (’22), and Purdue University (’23). This conference offers a platform for collaboration and training across a diversity of scientific approaches focused on understanding and targeting the TME.